Blar i forfatter "Sætrom, Pål"

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    • Associations of gene expression in blood with BMI and weight changes among women in the Norwegian Women and Cancer postgenome cohort 

      Baiju, Nikita; Rylander, Karin Charlotta Maria; Sætrom, Pål; Sandanger, Torkjel M; Nøst, Therese Haugdahl (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-07)
      Objective: This study aimed to evaluate associations between blood gene expression profiles and (1) current BMI and (2) past weight changes (WCs) among women who had never been diagnosed with cancer in the Norwegian Women and Cancer (NOWAC) postgenome cohort.<p> <p>Methods: This cross-sectional study (N = 1694) used gene expression profiles and information from three questionnaires: Q1 (baseline), ...

    • Gene expression in blood reflects smoking exposure among cancer-free women in the Norwegian Women and Cancer (NOWAC) postgenome cohort 

      Baiju, Nikita; Sandanger, Torkjel M; Sætrom, Pål; Nøst, Therese Haugdahl (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-12)
      Active smoking has been linked to modulated gene expression in blood. However, there is a need for a more thorough understanding of how quantitative measures of smoking exposure relate to differentially expressed genes (DEGs) in whole-blood among ever smokers. This study analysed microarray-based gene expression profiles from whole-blood samples according to smoking status and quantitative measures ...

    • In utero exposure to endocrine disrupting chemicals, micro-RNA profiles, and fetal growth: a pilot study protocol 

      Larose, Tricia L; Sætrom, Pål; Martinussen, Marit; Skogseth, Haakon; Sandanger, Torkjel M; Scélo, Ghislaine; McHale, Cliona M; Jacobsen, Geir Wenberg; Smith, Martyn T (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-05)
      <i>Background</i>: The developing fetus is particularly vulnerable to the effects of endocrine disrupting chemicals (EDCs). Molecular fingerprints of EDCs can be identified via microRNA (miRNA) expression profiles and may be etiologically implicated in the developmental origin of disease (DOHaD).<p> <p><i>Methods/design</i>: This pilot study includes pregnant women at high risk (smoking at ...

    • Increased expression of individual genes in whole blood is associated with late-stage lung cancer at and close to diagnosis 

      Urbarova, Ilona Halva; Skogholt, Anne Heidi; Sun, Yi-Qian; Mai, Xiao-Mei; Grønberg, Bjørn Henning; Sandanger, Torkjel Manning; Sætrom, Pål; Nøst, Therese Haugdahl (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-25)
      Lung cancer (LC) mortality rates are still increasing globally. As survival is linked to stage, there is a need to identify markers for earlier LC diagnosis and individualized treatment. The whole blood transcriptome of LC patients represents a source of potential LC biomarkers. We compared expression of > 60,000 genes in whole blood specimens taken from LC cases at diagnosis (n = 128) and controls ...

    • Increased levels of microRNA-320 in blood serum and plasma is associated with imminent and advanced lung cancer 

      Nøst, Therese Haugdahl; Skogholt, Anne Heidi; Urbarova, Ilona Halva; Mjelle, Robin; Paulsen, Erna-Elise; Dønnem, Tom; Andersen, Sigve; Markaki, Maria; Røe, Oluf Dimitri; Johansson, Mikael; Johansson, Mattias; Grønberg, Bjørn Henning; Sandanger, Torkjel M; Sætrom, Pål (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-07)
      Lung cancer (LC) incidence is increasing globally and altered levels of microRNAs (miRNAs) in blood may contribute to identification of individuals with LC. We identified miRNAs differentially expressed in peripheral blood at LC diagnosis and evaluated, in pre-diagnostic blood specimens, how long before diagnosis expression changes of such candidate miRNAs could be detected. We identified upregulated ...